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Tissue Inhibitors of Metalloproteinase 3 (TIMP3) Antibody

Catalogue No: abx001273
Price: £120.00
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Tissue Inhibitors of Metalloproteinase 3 (TIMP3) Antibody

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TIMP3 Antibody is a Rabbit Polyclonal antibody against TIMP3. TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function. In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with α3β1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects. TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression , wound healing, and vascular remodeling (6,7). Mutations in TIMP3 are associated with Sorsby's fundus dystrophy.

Target TIMP3
Clonality Polyclonal
Reactivity Human, Mouse, Rat, Monkey
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human TIMP3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P35625 (UniProt, ExPASy)
UniProt Secondary AC B2RBY9, Q5THV4, Q9UC74, Q9UGS2
UniProt Entry Name TIMP3_HUMAN
Gene Symbol TIMP3
GeneID 7078
String 9606.ENSP00000266085
Molecular Weight Calculated MW: 24 kDa
Observed MW: 38 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Tissue Inhibitors of Metalloproteinase 3 (TIMP3) Antibody

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