+44 (0) 1223 755950
+1 832 327 7413
Metalloproteinase Inhibitor 3 (TIMP3) Antibody
REQUEST MORE INFO
Catalogue No: abx001273
Price:
US$348.00
(Size: 60 µl)
Orders to United States ship from United States
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
TIMP3 Antibody is a Rabbit Polyclonal antibody against TIMP3. TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function. In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with α3β1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects. TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression , wound healing, and vascular remodeling (6,7). Mutations in TIMP3 are associated with Sorsby's fundus dystrophy.
Research Articles on Metalloproteinase Inhibitor 3 (TIMP3)
| Target | Metalloproteinase Inhibitor 3 (TIMP3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human TIMP3 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P35625 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RBY9, Q5THV4, Q9UC74, Q9UGS2 |
| UniProt Entry Name | TIMP3_HUMAN |
| Gene Symbol | TIMP3 |
| GeneID | 7078 |
| NCBI Accession | NP_000353.1 |
| KEGG | hsa:7078 |
| String | 9606.ENSP00000266085 |
| Molecular Weight | Calculated MW: 24 kDa Observed MW: 20 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
