Toll/interleukin-1 Receptor Domain-Containing Adapter Protein (TIRAP) Antibody
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Catalogue No: abx001586
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US$217.50
(Size: 20 µl)
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Datasheet SDS
TIRAP Antibody is a Rabbit Polyclonal antibody against TIRAP. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Research Articles on Toll/interleukin-1 Receptor Domain-Containing Adapter Protein (TIRAP)
| Target | Toll/interleukin-1 Receptor Domain-Containing Adapter Protein (TIRAP) |
| Research Area | Signal Transduction |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P58753-1 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KW65, Q56UH9, Q56UI0, Q8N5E5 |
| UniProt Entry Name | TIRAP_HUMAN |
| Gene Symbol | TIRAP |
| GeneID | 114609 |
| NCBI Accession | NP_001034750.1 |
| Molecular Weight | Calculated MW: 24 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1.25 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |