Toll/interleukin-1 Receptor Domain-Containing Adapter Protein (TIRAP) Antibody

Catalogue No: abx001586
Price: £120.00
(Size: 20 µl)
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TIRAP Antibody is a Rabbit Polyclonal antibody against TIRAP. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Target TIRAP
Clonality Polyclonal
Reactivity Human
Tested Applications IHC
Host Rabbit
Recommended dilutions IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P58753-1 (UniProt, ExPASy)
UniProt Secondary AC B3KW65, Q56UH9, Q56UI0, Q8N5E5
UniProt Entry Name TIRAP_HUMAN
Gene Symbol TIRAP
GeneID 114609
NCBI Accession NP_001034750.1
Molecular Weight Calculated MW: 23 kDa, 25 kDa, 27 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 1.25 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on TIRAP

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