Human Tissue Inhibitor of Metalloprotease 2 (TIMP2) Enzyme

Human Tissue Inhibitor of Metalloprotease 2 (TIMP2) Enzyme is a recombinant enzyme produced in HEK cells. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].

Target	Tissue Inhibitor of Metalloprotease 2 (TIMP2)
Research Area	Tumor Immunity, Cancer
Origin	Human
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	HEK293 cells
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Form	Lyophilized
Purity	> 95% (SDS-PAGE)
Storage	Store lyophilized or reconstituted below -18°C for long-term storage. Store reconstituted at 4°C for up to 7 days. Avoid repeated freeze/thaw cycles.
Shelf Life	12 months.
Stability	Stable at room temperature for up to 3 weeks.
UniProt Primary AC	P16035 (UniProt, ExPASy)
UniProt Secondary AC	Q16121, Q93006, Q9UDF7
UniProt Entry Name	TIMP2_HUMAN
KEGG	hsa:7077
String	9606.ENSP00000262768
Availability	Shipped within 5-10 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Tissue Inhibitor of Metalloprotease 2 (TIMP2)

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