Toll Like Receptor 2 (TLR2) Antibody

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

Target	Toll Like Receptor 2 (TLR2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 212-242 amino acids from the N-terminal region of human TLR2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O60603 (UniProt, ExPASy)
UniProt Secondary AC	B3Y612, D1CS45, D1CS48, D1CS49, O15454, Q8NI00
Gene Symbol	TLR2
GeneID	7097
OMIM	246300
NCBI Accession	NP_003255.2
HGNC	11848
KEGG	hsa:7097
Ensembl	ENSG00000137462
String	9606.ENSP00000260010
Molecular Weight	Calculated MW: 89.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey TLR2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Toll Like Receptor 2 (TLR2)

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