Toll Like Receptor 4 (TLR4) Antibody

TLR4 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.

Target	Toll Like Receptor 4 (TLR4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 669-698 amino acids from the Central region of human TLR4.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00206 (UniProt, ExPASy)
Gene Symbol	TLR4
Molecular Weight	Calculated MW: 95.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow, Pig, Hamster and Horse TLR4.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Toll Like Receptor 4 (TLR4)

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