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Toll Like Receptor 8 (TLR8) Antibody

Catalogue No: abx001263
Price: £120.00
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Toll Like Receptor 8 (TLR8) Antibody Toll Like Receptor 8 (TLR8) Antibody

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TLR8 Antibody is a Rabbit Polyclonal antibody against TLR8. The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NF˚B signaling pathway, suggesting that they play a role in the immune response.

Target Toll Like Receptor 8 (TLR8)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human TLR8.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9NR97 (UniProt, ExPASy)
UniProt Secondary AC B3Y654, D1CS70, D1CS76, Q495P4, Q6UXL6, Q9NYG9
UniProt Entry Name TLR8_HUMAN
Gene Symbol TLR8
GeneID 51311
String 9606.ENSP00000312082
Molecular Weight Calculated MW: 119 kDa, 121 kDa
Observed MW: 115 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Toll Like Receptor 8 (TLR8) Antibody

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