Tumor Necrosis Factor (TNF) Antibody
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Catalogue No: abx012258
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Tumor Necrosis Factor (Tumor Necrosis Factor) is an important cytokine produced by numerous cell types including neutrophils, activated lymphocytes, macrophages and NK cells. It plays a critical role in inflammatory responses and in apoptosis. Tumor Necrosis Factor is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. Tumor Necrosis Factor exists as a multimer of two, three, or five non covalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. Although it has little effect on many cultured normal human cells, Tumor Necrosis Factor appears to be directly toxic to vascular endothelial cells. Other actions of Tumor Necrosis Factor include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. Tumor Necrosis Factor is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Research Articles on Tumor Necrosis Factor (TNF)
| Target | Tumor Necrosis Factor (TNF) |
| Research Area | Cellular Differentiation and Adhesion, Tumor Immunity, Hormone Metabolism, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant Human TNF-alpha (BioSource company, Cat.No. PHC3013). |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P01375 (UniProt, ExPASy) |
| UniProt Secondary AC | O43647, Q9P1Q2, Q9UIV3 |
| UniProt Entry Name | TNFA_HUMAN |
| Gene Symbol | TNF |
| GeneID | 7124 |
| OMIM | 191160 |
| HGNC | 11892 |
| KEGG | hsa:7124 |
| Ensembl | ENSG00000232810 |
| String | 9606.ENSP00000398698 |
| Molecular Weight | 17.4 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |