Tumor Necrosis Factor (TNF) Antibody
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Catalogue No: abx027445
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US$326.25
(Size: 80 µl)
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Datasheet SDS
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Research Articles on Tumor Necrosis Factor (TNF)
| Target | Tumor Necrosis Factor (TNF) |
| Research Area | Cytokines, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 187-216 amino acids from the C-terminal region of human TNF. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P01375 (UniProt, ExPASy) |
| UniProt Secondary AC | O43647, Q9P1Q2, Q9UIV3 |
| UniProt Entry Name | TNFA_HUMAN |
| Gene Symbol | TNF |
| GeneID | 7124 |
| OMIM | 191160 |
| HGNC | 11892 |
| KEGG | hsa:7124 |
| Ensembl | ENSG00000232810 |
| String | 9606.ENSP00000398698 |
| Molecular Weight | Calculated MW: 25.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |