Tumor Necrosis Factor (TNF) Antibody
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Catalogue No: abx117001
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US$522.00
(Size: 100 µl)
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Datasheet SDS
TNF Antibody is a Rabbit Polyclonal antibody against TNF. TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane proteinMembrane-bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to geneRate a soluble homotrimerBoth membrane and soluble forms of TNF-α are biologically activeTNF-α is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophagesCellular response to TNF-α is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological contextActivation of kinase pathways (including JNK, Erk (p44/42), p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-α-mediated activation of caspase-8 leads to programmed cell deathTNF-α plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosisThe role of TNF-α in autoimmunity is underscored by blocking TNF-α action to treat rheumatoid arthritis and Crohn’s diseaseThis protein is involved in Immunology.
Research Articles on Tumor Necrosis Factor (TNF)
| Target | Tumor Necrosis Factor (TNF) |
| Research Area | Cytokines, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | C term -peptide of human SFPQ. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P01375 (UniProt, ExPASy) |
| UniProt Secondary AC | O43647, Q9P1Q2, Q9UIV3 |
| UniProt Entry Name | TNFA_HUMAN |
| Gene Symbol | TNF |
| GeneID | 7124 |
| OMIM | 191160 |
| HGNC | 11892 |
| KEGG | hsa:7124 |
| Ensembl | ENSG00000232810 |
| String | 9606.ENSP00000398698 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |