TNF Receptor-Associated Factor 1 (TRAF1) Antibody

TNF Receptor-Associated Factor 1 (TRAF1) Antibody is a Rabbit Polyclonal antibody for the detection of TRAF1.

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

Target	TNF Receptor-Associated Factor 1 (TRAF1)
Research Area	Tumor Immunity, Cancer
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	TNF receptor-associated factor 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life	12 months.
UniProt Primary AC	Q13077 (UniProt, ExPASy)
UniProt Secondary AC	B4DJ77, Q658U1, Q8NF13
UniProt Entry Name	TRAF1_HUMAN
Gene Symbol	TRAF1
GeneID	7185
OMIM	601711
HGNC	12031
KEGG	hsa:7185
Ensembl	ENSG00000056558
String	9606.ENSP00000362994
Molecular Weight	Observed MW: 46 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on TNF Receptor-Associated Factor 1 (TRAF1)

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