Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B) Antibody

TNFRSF10B Antibody is a Rabbit Polyclonal antibody against TNFRSF10B. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Target	Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 260-440 of human DR5/TRAILR2/TNFRSF10B.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14763 (UniProt, ExPASy)
UniProt Secondary AC	O14720, O15508, O15517, O15531, Q6UXM8, Q7Z360, Q9BVE0
UniProt Entry Name	TR10B_HUMAN
Gene Symbol	TNFRSF10B
GeneID	8795
NCBI Accession	NP_003833.4
KEGG	hsa:8795
String	9606.ENSP00000276431
Molecular Weight	Calculated MW: 48 kDa Observed MW: 48 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tumor Necrosis Factor Receptor Superfamily Member 10B / DR5 (TNFRSF10B)

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