Tumor Necrosis Factor Receptor Superfamily Member 11B (TNFRSF11B) Antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily.This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption.This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development.Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification.Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Target	Tumor Necrosis Factor Receptor Superfamily Member 11B (TNFRSF11B)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human TNFRSF11B expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00300 (UniProt, ExPASy)
UniProt Secondary AC	B2R9A8, O60236, Q53FX6, Q9UHP4
UniProt Entry Name	TR11B_HUMAN
Gene Symbol	TNFRSF11B
GeneID	4982
OMIM	239000
HGNC	11909
KEGG	hsa:4982
Ensembl	ENSG00000164761
String	9606.ENSP00000297350
Molecular Weight	60 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tumor Necrosis Factor Receptor Superfamily Member 11B (TNFRSF11B)

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