Tumor Necrosis Factor Receptor Superfamily Member 11B (TNFRSF11B) Antibody
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Catalogue No: abx027571
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US$326.25
(Size: 80 µl)
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Datasheet SDS
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Research Articles on Tumor Necrosis Factor Receptor Superfamily Member 11B (TNFRSF11B)
| Target | Tumor Necrosis Factor Receptor Superfamily Member 11B (TNFRSF11B) |
| Research Area | Cytokines, Metabolic Pathways, Bone Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 243-271 amino acids from the Central region of human TNFRSF11B. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O00300 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R9A8, O60236, Q53FX6, Q9UHP4 |
| UniProt Entry Name | TR11B_HUMAN |
| Gene Symbol | TNFRSF11B |
| KEGG | hsa:4982 |
| String | 9606.ENSP00000297350 |
| Molecular Weight | Calculated MW: 46 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |