Tumor Necrosis Factor Receptor Superfamily Member 1B / CD120b (TNFRSF1B) Antibody

TNFRSF1B Antibody is a Rabbit Polyclonal antibody against TNFRSF1B. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Target	Tumor Necrosis Factor Receptor Superfamily Member 1B / CD120b (TNFRSF1B)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 295-377 of human TNFR2/TNFRSF1B.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P20333 (UniProt, ExPASy)
UniProt Secondary AC	B1AJZ3, Q16042, Q6YI29, Q9UIH1
Gene Symbol	TNFRSF1B
GeneID	7133
NCBI Accession	NP_001057.1
Molecular Weight	Calculated MW: 48 kDa Observed MW: 75 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tumor Necrosis Factor Receptor Superfamily Member 1B / CD120b (TNFRSF1B)

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