Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody

TNFSF10 Antibody is a Rabbit Polyclonal antibody against TNFSF10. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TNFSF10.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P50591 (UniProt, ExPASy)
UniProt Secondary AC	A1Y9B3
UniProt Entry Name	TNF10_HUMAN
Gene Symbol	TNFSF10
GeneID	8743
NCBI Accession	NP_003801.1
KEGG	hsa:8743
String	9606.ENSP00000241261
Molecular Weight	Calculated MW: 33 kDa Observed MW: 28 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	1.33 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10)

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