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Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody

Catalogue No: abx001750
Price: £120.00
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Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody

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TNFSF10 Antibody is a Rabbit Polyclonal antibody against TNFSF10. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human TNFSF10.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P50591 (UniProt, ExPASy)
UniProt Secondary AC A1Y9B3
UniProt Entry Name TNF10_HUMAN
Gene Symbol TNFSF10
GeneID 8743
KEGG hsa:8743
String 9606.ENSP00000241261
Molecular Weight Calculated MW: 11 kDa, 32 kDa
Observed MW: 27 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody

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