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TNFSF11 Antibody is a Rabbit Polyclonal antibody against TNFSF11. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Research Articles on Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody
||Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11)
||WB, IHC, IF/ICC
||WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
||Recombinant protein of human TNFSF11.
||Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
|UniProt Primary AC
|UniProt Secondary AC
||O14723, Q96Q17, Q9P2Q3
||Calculated MW: 27 kDa, 30 kDa, 35 kDa
Observed MW: 32 kDa
||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
||> 1 mg/ml
||Shipped within 5-10 working days.
||This product is for research use only.