Tumor Necrosis Factor Ligand Superfamily Member 12 (TNFSF12) Antibody

TNFSF12 Antibody is a Rabbit Polyclonal antibody against TNFSF12. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Target	Tumor Necrosis Factor Ligand Superfamily Member 12 (TNFSF12)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 42-123 of human TNFSF12.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O43508 (UniProt, ExPASy)
UniProt Secondary AC	Q8IZK7, Q8WUZ7
UniProt Entry Name	TNF12_HUMAN
Gene Symbol	TNFSF12
GeneID	8742
NCBI Accession	NP_003800.1
KEGG	hsa:407977 hsa:8742
String	9606.ENSP00000293825
Molecular Weight	Calculated MW: 27 kDa Observed MW: 27 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tumor Necrosis Factor Ligand Superfamily Member 12 (TNFSF12)

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