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Tyrosine Kinase Non Receptor 1 (TNK1) Antibody
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Catalogue No: abx012267
Price:
US$427.75
(Size: 100 µl)
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TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase (NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Research Articles on Tyrosine Kinase Non Receptor 1 (TNK1)
| Target | Tyrosine Kinase Non Receptor 1 (TNK1) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of TNK1 (aa451-560) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13470 (UniProt, ExPASy) |
| UniProt Secondary AC | O95364, Q8IYI4 |
| UniProt Entry Name | TNK1_HUMAN |
| Gene Symbol | TNK1 |
| GeneID | 8711 |
| OMIM | 608076 |
| HGNC | 11940 |
| KEGG | hsa:8711 |
| Ensembl | ENSG00000174292 |
| String | 9606.ENSP00000459799 |
| Molecular Weight | 73 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |