Troponin I, Fast Skeletal Muscle (TNNI2) Antibody
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Catalogue No: abx011978
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
Research Articles on Troponin I, Fast Skeletal Muscle (TNNI2)
| Target | Troponin I, Fast Skeletal Muscle (TNNI2) |
| Research Area | Cardiovascular Biology |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human TNNI2 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P48788 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NIV8, A6NJU5 |
| UniProt Entry Name | TNNI2_HUMAN |
| Gene Symbol | TNNI2 |
| GeneID | 7136 |
| OMIM | 191043 |
| HGNC | 11946 |
| KEGG | hsa:7136 |
| Ensembl | ENSG00000130598 |
| String | 9606.ENSP00000371331 |
| Molecular Weight | 21 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |