Troponin I, Fast Skeletal Muscle (TNNI2) Antibody

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Catalogue No: abx016011
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits.The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction.Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function.In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha.This protein also suppresses tumor growth in human ovarian carcinoma.Mutations in this gene cause myopathy and distal arthrogryposis type 2B.Alternatively spliced transcript variants have been found for this gene.

Target Troponin I, Fast Skeletal Muscle (TNNI2)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, IF/ICC, FCM
Host Mouse
Recommended dilutions ELISA: 1/10000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human TNNI2 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Purified from ascites by Protein G chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P48788 (UniProt, ExPASy)
UniProt Secondary AC A6NIV8, A6NJU5
UniProt Entry Name TNNI2_HUMAN
Gene Symbol TNNI2
GeneID 7136
OMIM 191043
HGNC 11946
KEGG hsa:7136
Ensembl ENSG00000130598
String 9606.ENSP00000371331
Molecular Weight 21 kDa
Buffer PBS, containing 0.05% sodium azide.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Troponin I, Fast Skeletal Muscle (TNNI2)


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