Cellular Tumor Antigen p53 Phospho-Thr18 (TP53 pT18) Antibody
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Catalogue No: abx000511
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US$232.00
(Size: 20 µl)
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Datasheet SDS
TP53 (pT18) Antibody is a Rabbit Polyclonal antibody against TP53 (pT18). This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).
Research Articles on Cellular Tumor Antigen P53 Phospho-Thr18 (TP53 pT18)
| Target | Cellular Tumor Antigen P53 Phospho-Thr18 (TP53 pT18) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around T18 of human p53. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04637 (UniProt, ExPASy) |
| UniProt Secondary AC | Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61 |
| UniProt Entry Name | P53_HUMAN |
| Gene Symbol | TP53 |
| GeneID | 7157 |
| OMIM | 133239 |
| NCBI Accession | NP_000537.3 |
| HGNC | 11998 |
| KEGG | hsa:7157 |
| Ensembl | ENSG00000141510 |
| String | 9606.ENSP00000269305 |
| Molecular Weight | Calculated MW: 44 kDa Observed MW: 54 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |