Tripeptidyl Peptidase I (TPP1) Antibody

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Target	Tripeptidyl Peptidase I (TPP1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human TPP1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14773 (UniProt, ExPASy)
UniProt Secondary AC	Q53HT1, Q5JAK6, Q6UX56, Q71JP6, Q96C37
UniProt Entry Name	TPP1_HUMAN
Gene Symbol	TPP1
KEGG	hsa:1200
String	9606.ENSP00000299427
Molecular Weight	Calculated MW: 61.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey TPP1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tripeptidyl Peptidase I (TPP1)

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