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Tryptase Alpha/beta-1 (TPSAB1) Antibody

Catalogue No: abx001641
Price: £120.00
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Tryptase Alpha/beta-1 (TPSAB1) Antibody Tryptase Alpha/beta-1 (TPSAB1) Antibody

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TPSAB1 Antibody is a Rabbit Polyclonal antibody against TPSAB1. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Target TPSAB1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human TPSAB1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15661 (UniProt, ExPASy)
UniProt Entry Name TRYB1_HUMAN
Gene Symbol TPSAB1
GeneID 7177
KEGG hsa:7177
String 9606.ENSP00000343577
Molecular Weight Calculated MW: 29 kDa, 30 kDa
Observed MW: 33 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Tryptase Alpha/beta-1 (TPSAB1) Antibody

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