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TNF Receptor-Associated Factor 1 (TRAF1) Antibody
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Catalogue No: abx000575
Price:
US$203.00
(Size: 20 µl)
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TRAF1 Antibody is a Rabbit Polyclonal antibody against TRAF1. TRAF1 is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. TRAF1 and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. TRAF1 is observed at 45-50 kDa in western blotting, and the additional bands of lower molecular weight (~30 kDa) may represent TRAF1 cleavage fragments, similar to the results obtained by the article (PMID:11098060).
Research Articles on TNF Receptor-Associated Factor 1 (TRAF1)
| Target | TNF Receptor-Associated Factor 1 (TRAF1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 217-416 of human TRAF1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13077 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DJ77, Q658U1, Q8NF13 |
| UniProt Entry Name | TRAF1_HUMAN |
| Gene Symbol | TRAF1 |
| GeneID | 7185 |
| NCBI Accession | NP_005649.1 |
| KEGG | hsa:7185 |
| String | 9606.ENSP00000362994 |
| Molecular Weight | Calculated MW: 46 kDa Observed MW: 50 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
