TNF Receptor Associated Factor 2 (TRAF2) Antibody

Catalogue No: abx000916
Price: £160.00
(Size: 20 µl)
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TNF Receptor Associated Factor 2 (TRAF2) Antibody TNF Receptor Associated Factor 2 (TRAF2) Antibody TNF Receptor Associated Factor 2 (TRAF2) Antibody

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TRAF2 Antibody is a Rabbit Polyclonal antibody against TRAF2. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Target TRAF2
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human TRAF2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q12933 (UniProt, ExPASy)
UniProt Secondary AC A8K107, B4DPJ7, Q7Z337, Q96NT2
UniProt Entry Name TRAF2_HUMAN
Gene Symbol TRAF2
GeneID 7186
KEGG hsa:7186
String 9606.ENSP00000247668
Molecular Weight Calculated MW: 53 kDa, 54 kDa, 55 kDa, 61 kDa
Observed MW: 54 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on TNF Receptor Associated Factor 2 (TRAF2) Antibody

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