Transcription Factor SOX-2 (SOX2) Antibody

Transcription Factor SOX-2 (SOX2) Antibody is a Mouse Monoclonal antibody for the detection of SOX2.

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Target	Transcription Factor SOX-2 (SOX2)
Clonality	Monoclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	SRY(sex determining region Y)-box 2
Isotype	IgG1
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P48431 (UniProt, ExPASy)
UniProt Secondary AC	Q14537
UniProt Entry Name	SOX2_HUMAN
Gene Symbol	SOX2
GeneID	6657
OMIM	184429
HGNC	11195
KEGG	hsa:6657
Ensembl	ENSG00000181449
String	9606.ENSP00000323588
Molecular Weight	Observed MW: 34 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Transcription Factor SOX-2 (SOX2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue