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Transcription Factor SOX-2 (SOX2) Antibody
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Catalogue No: abx240016
Price:
US$406.00
(Size: 100 µg)
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Transcription Factor SOX-2 (SOX2) Antibody is a Mouse Monoclonal antibody for the detection of SOX2. Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Research Articles on Transcription Factor SOX-2 (SOX2)
| Target | Transcription Factor SOX-2 (SOX2) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | SRY(sex determining region Y)-box 2 |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P48431 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14537 |
| UniProt Entry Name | SOX2_HUMAN |
| Gene Symbol | SOX2 |
| GeneID | 6657 |
| OMIM | 184429 |
| HGNC | 11195 |
| KEGG | hsa:6657 |
| Ensembl | ENSG00000181449 |
| String | 9606.ENSP00000323588 |
| Molecular Weight | Observed MW: 34 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |