E3 Ubiquitin-Protein Ligase TRIM63 (TRIM63) Antibody

TRIM63 Antibody is a Rabbit Polyclonal antibody against TRIM63. This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.

Target	E3 Ubiquitin-Protein Ligase TRIM63 (TRIM63)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 253-353 of human TRIM63.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q969Q1 (UniProt, ExPASy)
UniProt Secondary AC	B4DN95, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4
UniProt Entry Name	TRI63_HUMAN
Gene Symbol	TRIM63
GeneID	84676
OMIM	606131
NCBI Accession	NP_115977.2
HGNC	16007
KEGG	hsa:84676
Ensembl	ENSG00000158022
String	9606.ENSP00000363390
Molecular Weight	Calculated MW: 40 kDa Observed MW: 47 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on E3 Ubiquitin-Protein Ligase TRIM63 (TRIM63)

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