Radical S-Adenosyl Methionine Domain Containing 2 (TRIP10) Antibody

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4, 5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Target	Radical S-Adenosyl Methionine Domain Containing 2 (TRIP10)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 115-144 amino acids from the N-terminal region of human TRIP10.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15642 (UniProt, ExPASy)
UniProt Entry Name	CIP4_HUMAN
KEGG	hsa:9322
String	9606.ENSP00000320117
Molecular Weight	Calculated MW: 68.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat TRIP10.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Radical S-Adenosyl Methionine Domain Containing 2 (TRIP10)

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