Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8) Antibody
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Catalogue No: abx026431
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Research Articles on Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8)
| Target | Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 263-292 amino acids from the Central region of human TRPM8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q7Z2W7 (UniProt, ExPASy) |
| UniProt Secondary AC | A0AVG2, Q3YFM7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1 |
| UniProt Entry Name | TRPM8_HUMAN |
| KEGG | hsa:79054 |
| String | 9606.ENSP00000323926 |
| Molecular Weight | Calculated MW: 128 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |