TSC2 (pS1387) Antibody

Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Target	TSC2 (pS1387)
Clonality	Polyclonal
Target Modification	Ser1387
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, IF/ICC, DB
Host	Rabbit
Recommended dilutions	IF/ICC: 1/10 - 1/50, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1387 of human TSC2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49815 (UniProt, ExPASy)
UniProt Entry Name	TSC2_HUMAN
NCBI Accession	NP_000539.2 NP_001070651.1 NP_001107854.1
KEGG	hsa:7249
String	9606.ENSP00000219476
Molecular Weight	Calculated MW: 201 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat TSC2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TSC2 (pS1387)

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