TSC2 (pS1798) Antibody

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Catalogue No: abx032001
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Target TSC2 (pS1798)
Clonality Polyclonal
Target Modification Ser1798
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, IF/ICC, DB
Host Rabbit
Recommended dilutions IF/ICC: 1/10 - 1/50, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1798 of human TSC2.
Isotype IgG
Form Liquid
Purification Purified in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P49815 (UniProt, ExPASy)
UniProt Entry Name TSC2_HUMAN
KEGG hsa:7249
String 9606.ENSP00000219476
Molecular Weight Calculated MW: 201 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on TSC2 (pS1798)


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