Dual Specificity Protein Kinase TTK (TTK) Antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Target	Dual Specificity Protein Kinase TTK (TTK)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human TTK (MPS1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P33981 (UniProt, ExPASy)
UniProt Secondary AC	A8K8U5, B2RDW2, E1P543, Q15272, Q5TCS0, Q9BW51, Q9NTM0
UniProt Entry Name	TTK_HUMAN
KEGG	hsa:7272
String	9606.ENSP00000358813
Molecular Weight	Calculated MW: 97.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey TTK.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dual Specificity Protein Kinase TTK (TTK)

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