Transthyretin (TTR) Antibody

Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Target	Transthyretin (TTR)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/25, IF/ICC: 1/25, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 71-98 amino acids from the C-terminal region of human TTR.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P02766 (UniProt, ExPASy)
UniProt Secondary AC	Q549C7, Q6IB96, Q9UBZ6, Q9UCM9
UniProt Entry Name	TTHY_HUMAN
Gene Symbol	TTR
NCBI Accession	NP_000362.1
KEGG	hsa:7276
String	9606.ENSP00000237014
Molecular Weight	Calculated MW: 15.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey TTR.
Concentration	0.50 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transthyretin (TTR)

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