Tubulin Beta 3 (TUBB3) Antibody

Tubulin, beta 3, also known as TUBB3. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non exchangeable site on the alpha chain. Tubulin is a highly conserved protein with a molecular weight of ~50 kD. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. The two main tubulin isoforms, alpha and beta tubulin, are usually products of separate genes. The beta tubulin family includes six expressed genes that produce the polypeptide isoforms known as Classes I through VI, each of which have a distinct pattern of expression. Class III beta tubulin is found in neurons and mammalian testis cells and is widely used as a neuronal marker in developmental neurobiology, neoplasia, and stem cell research. Class III beta tubulin expression in neuronal and neuroblastic tumors is differentiation dependent, and its expression in certain non-neuronal neoplasms has been associated with poor prognosis and/or resistance to chemotherapy.

Target	Tubulin Beta 3 (TUBB3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human TUBB3 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13509 (UniProt, ExPASy)
UniProt Secondary AC	A8K854, Q9BTZ0, Q9BW10
UniProt Entry Name	TBB3_HUMAN
Gene Symbol	TUBB3
GeneID	10381
OMIM	600638
HGNC	20772
KEGG	hsa:10381
Ensembl	ENSG00000258947
String	9606.ENSP00000320295
Molecular Weight	50 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tubulin Beta 3 (TUBB3)

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