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Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody
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Catalogue No: abx239894
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody is a Mouse Monoclonal antibody for the detection of RANKL. TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Research Articles on Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11)
| Target | Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) |
| Research Area | Signal Transduction, Metabolic Pathways, Apoptosis, Tumor Immunity, Bone Metabolism, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | tumor necrosis factor (ligand) superfamily, member 11 |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O14788 (UniProt, ExPASy) |
| UniProt Secondary AC | O14723, Q96Q17, Q9P2Q3 |
| Gene Symbol | TNFSF11 |
| GeneID | 8600 |
| OMIM | 259710 |
| HGNC | 11926 |
| Ensembl | ENSG00000120659 |
| Molecular Weight | Observed MW: 35 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |