Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD) Antibody
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Catalogue No: abx012271
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US$420.50
(Size: 100 µg)
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Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD) Antibody is a Rabbit Polyclonal antibody for the detection of TRADD. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Research Articles on Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD)
| Target | Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD) |
| Research Area | Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | TNFRSF1A-associated via death domain |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q15628 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RDS3, B3KQZ9, Q52NZ1 |
| UniProt Entry Name | TRADD_HUMAN |
| Gene Symbol | TRADD |
| GeneID | 8717 |
| OMIM | 603500 |
| HGNC | 12030 |
| KEGG | hsa:8717 |
| Ensembl | ENSG00000102871 |
| String | 9606.ENSP00000341268 |
| Molecular Weight | Observed MW: 34 kDa, 27 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |