Thioredoxin / TRX (TXN) Antibody
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Catalogue No: abx034701
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Research Articles on Thioredoxin / TRX (TXN)
| Target | Thioredoxin / TRX (TXN) |
| Research Area | Metabolism, Developmental Science |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human TXN. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P10599 (UniProt, ExPASy) |
| UniProt Secondary AC | B1ALW1, O60744, Q53X69, Q96KI3, Q9UDG5 |
| UniProt Entry Name | THIO_HUMAN |
| Gene Symbol | TXN |
| GeneID | 7295 |
| OMIM | 187700 |
| NCBI Accession | NP_001231867.1 NP_003320.2 |
| HGNC | 12435 |
| KEGG | hsa:7295 |
| Ensembl | ENSG00000136810 |
| String | 9606.ENSP00000363641 |
| Molecular Weight | Calculated MW: 11.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow, Pig and Rabbit TXN. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |