Tyrosinase (TYR) Antibody

TYR Antibody is a Rabbit Polyclonal antibody against TYR. The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008].

Target	Tyrosinase (TYR)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 20-340 of human Tyrosinase.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P14679 (UniProt, ExPASy)
UniProt Secondary AC	Q15675, Q15676, Q15680, Q8TAK4, Q9BYY0, Q9BZX1
UniProt Entry Name	TYRO_HUMAN
Gene Symbol	TYR
GeneID	7299
NCBI Accession	NP_000363.1
KEGG	hsa:7299
String	9606.ENSP00000263321
Molecular Weight	Calculated MW: 60 kDa Observed MW: 80 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosinase (TYR)

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