Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3) Antibody

Tyro3 (also known as Sky and Rse), with 890-amino acid protein (about 98kDa), belongs to the Axl/Tyro3 family of receptor tyrosine kinases, which also includes Axl and Mer.Gas6 (growth arrest-specific gene-6) is a ligand for all members of the Axl family and they play essential roles in spermatogenesis, immunoregulation, and phagocytosis.Tyro3 was expressed at high levels during postnatal development and in the adult in the cortex.Tyro3 and Gas6 have neurotrophic roles in the nervous system.In addition, the signalling interactions of Axl and Tyro3 may play roles in tumourigenesis, inflammation as well as other cell proliferative diseases.

Target	Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of TYRO3 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q06418 (UniProt, ExPASy)
UniProt Secondary AC	O14953, Q86VR3
UniProt Entry Name	TYRO3_HUMAN
Gene Symbol	TYRO3
GeneID	7301
OMIM	600341
HGNC	12446
KEGG	hsa:7301
Ensembl	ENSG00000092445
String	9606.ENSP00000263798
Molecular Weight	96 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase Receptor TYRO3 (TYRO3)

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