Tyrosine-Protein Kinase Receptor Tie-1 (TIE1) Antibody

TIE1 Antibody is a Rabbit Polyclonal antibody against TIE1. This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target	Tyrosine-Protein Kinase Receptor Tie-1 (TIE1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human TIE1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35590 (UniProt, ExPASy)
UniProt Secondary AC	B5A949, B5A950
UniProt Entry Name	TIE1_HUMAN
GeneID	7075
NCBI Accession	NP_005415.1
KEGG	hsa:7075
String	9606.ENSP00000361554
Molecular Weight	Calculated MW: 125 kDa Observed MW: 135/140 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase Receptor Tie-1 (TIE1)

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