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Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody
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Catalogue No: abx239864
Price:
US$406.00
(Size: 100 µg)
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Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody is a Rabbit Polyclonal antibody for the detection of USP2. Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
Research Articles on Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2)
| Target | Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | ubiquitin specific peptidase 2 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | O75604 (UniProt, ExPASy) |
| UniProt Secondary AC | B0YJB8, E9PPM2, Q8IUM2, Q8IW04, Q96MB9, Q9BQ21 |
| UniProt Entry Name | UBP2_HUMAN |
| Gene Symbol | USP2 |
| GeneID | 9099 |
| KEGG | hsa:9099 |
| String | 9606.ENSP00000260187 |
| Molecular Weight | Observed MW: 68 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |