Ubiquitin-Like Protein ATG12 (ATG12) Antibody
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Catalogue No: abx148392
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Ubiquitin-Like Protein ATG12 (ATG12) Antibody is a Rabbit Polyclonal antibody for the detection of ATG12. Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Research Articles on Ubiquitin-Like Protein ATG12 (ATG12)
| Target | Ubiquitin-Like Protein ATG12 (ATG12) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | ATG12 autophagy related 12 homolog(S. cerevisiae) |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O94817 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6PJV2 |
| UniProt Entry Name | ATG12_HUMAN |
| Gene Symbol | ATG12 |
| GeneID | 9140 |
| OMIM | 609608 |
| HGNC | 588 |
| KEGG | hsa:9140 |
| Ensembl | ENSG00000145782 |
| String | 9606.ENSP00000425107 |
| Molecular Weight | Observed MW: 48-50 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |