Mitochondrial Brown Fat Uncoupling Protein 1 (UCP1) Antibody
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Catalogue No: abx004494
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US$217.50
(Size: 20 µl)
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Datasheet SDS
UCP1 Antibody is a Rabbit Polyclonal antibody against UCP1. Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
Research Articles on Mitochondrial Brown Fat Uncoupling Protein 1 (UCP1)
| Target | Mitochondrial Brown Fat Uncoupling Protein 1 (UCP1) |
| Research Area | Signal Transduction |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/1000 - 1/5000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to UCP1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P25874 (UniProt, ExPASy) |
| UniProt Secondary AC | Q13218, Q4KMZ3, Q68G66 |
| UniProt Entry Name | UCP1_HUMAN |
| Gene Symbol | UCP1 |
| GeneID | 7350 |
| NCBI Accession | NP_068605.1 |
| KEGG | hsa:7350 |
| String | 9606.ENSP00000262999 |
| Molecular Weight | Calculated MW: 33 kDa Observed MW: 33 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |