Mitochondrial Uncoupling Protein 2 (UCP2) Antibody
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Catalogue No: abx003088
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US$348.00
(Size: 60 µl)
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Datasheet SDS
UCP2 Antibody is a Rabbit Polyclonal antibody against UCP2. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
Research Articles on Mitochondrial Uncoupling Protein 2 (UCP2)
| Target | Mitochondrial Uncoupling Protein 2 (UCP2) |
| Research Area | Developmental Science |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human UCP2 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P55851 (UniProt, ExPASy) |
| UniProt Secondary AC | Q4PJH8, Q53HM3 |
| UniProt Entry Name | UCP2_HUMAN |
| Gene Symbol | UCP2 |
| GeneID | 7351 |
| NCBI Accession | NP_003346.2 |
| KEGG | hsa:7351 |
| String | 9606.ENSP00000312029 |
| Molecular Weight | Calculated MW: 33 kDa Observed MW: 32 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
