Uromodulin (UMOD) Antibody
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Catalogue No: abx001568
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US$217.50
(Size: 20 µl)
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Datasheet SDS
UMOD Antibody is a Rabbit Polyclonal antibody against UMOD. The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
Research Articles on Uromodulin (UMOD)
| Target | Uromodulin (UMOD) |
| Research Area | Kidney Biomarkers |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to UMOD. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P07911 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KP48, B3KRN9, E9PEA4, Q540J6, Q6ZS84, Q8IYG0 |
| UniProt Entry Name | UROM_HUMAN |
| Gene Symbol | UMOD |
| GeneID | 7369 |
| NCBI Accession | NP_001008390.1 |
| KEGG | hsa:7369 |
| String | 9606.ENSP00000379438 |
| Molecular Weight | Calculated MW: 70 kDa Observed MW: 70 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1.52 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |