Uromodulin (UMOD) Antibody

UMOD Antibody is a Rabbit Polyclonal antibody against UMOD. The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.

Target	Uromodulin (UMOD)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 315-615 of human UMOD.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07911 (UniProt, ExPASy)
UniProt Secondary AC	B3KP48, B3KRN9, E9PEA4, Q540J6, Q6ZS84, Q8IYG0
UniProt Entry Name	UROM_HUMAN
Gene Symbol	UMOD
GeneID	7369
NCBI Accession	NP_001008390.1
KEGG	hsa:7369
String	9606.ENSP00000379438
Molecular Weight	Calculated MW: 70 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	1.52 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Uromodulin (UMOD)

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