Uridine 5'-Monophosphate Synthase (UMPS) Antibody

UMPS Antibody is a Rabbit Polyclonal antibody against UMPS. This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

Target	Uridine 5'-Monophosphate Synthase (UMPS)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 181-480 of human UMPS.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P11172 (UniProt, ExPASy)
UniProt Entry Name	UMPS_HUMAN
Gene Symbol	UMPS
GeneID	7372
NCBI Accession	NP_000364.1
KEGG	hsa:7372
String	9606.ENSP00000232607
Molecular Weight	Calculated MW: 52 kDa Observed MW: 56 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Uridine 5'-Monophosphate Synthase (UMPS)

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