Netrin Receptor UNC5C (UNC5C) Antibody

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

Target	Netrin Receptor UNC5C (UNC5C)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 88-117 amino acids from the N-terminal region of human UNC5C.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95185 (UniProt, ExPASy)
UniProt Secondary AC	Q8IUT0
UniProt Entry Name	UNC5C_HUMAN
Gene Symbol	UNC5C
KEGG	hsa:8633
String	9606.ENSP00000406022
Molecular Weight	Calculated MW: 103 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Netrin Receptor UNC5C (UNC5C)

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