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Urokinase-Type Plasminogen Activator / uPA (PLAU) Antibody
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Catalogue No: abx033923
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US$326.25
(Size: 80 µl)
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Datasheet SDS
PLAU, a member of the peptidase family S1, is a potent plasminogen activator and is clinically used for therapy of thrombolytic disorders. PLAU specifically cleaves the Arg-|-Val bond in plasminogen to form plasmin. The protein is found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A. Cleavage occurs after residue 155 in the low molecular mass form to yield a short A1 chain. The protein is used in Pulmonary Embolism (PE) to initiates fibrinolysis. Structurally, PLAU contains 1 EGF-like domain and 1 kringle domain.
Research Articles on Urokinase-Type Plasminogen Activator / uPA (PLAU)
| Target | Urokinase-Type Plasminogen Activator / uPA (PLAU) |
| Research Area | Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 396-426 amino acids from the C-terminal region of human Urokinase (PLAU). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P00749 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DPZ2, Q15844, Q16618, Q53XS3, Q5SWW9, Q969W6 |
| UniProt Entry Name | UROK_HUMAN |
| Gene Symbol | PLAU |
| GeneID | 5328 |
| OMIM | 191840 |
| HGNC | 9052 |
| KEGG | hsa:5328 |
| Ensembl | ENSG00000122861 |
| String | 9606.ENSP00000361850 |
| Molecular Weight | Calculated MW: 48.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |