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Regulator of Nonsense Transcripts 1 (UPF1) Antibody
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Catalogue No: abx001282
Price:
£120.00
(Size: 20 µl)
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UPF1 Antibody is a Rabbit Polyclonal antibody against UPF1. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
Research Articles on UPF1
| Target | UPF1 |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200, IP: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide of human UPF1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92900 (UniProt, ExPASy) |
| UniProt Secondary AC | O00239, O43343, Q86Z25, Q92842 |
| UniProt Entry Name | RENT1_HUMAN |
| Gene Symbol | UPF1 |
| GeneID | 5976 |
| KEGG | hsa:5976 |
| String | 9606.ENSP00000470142 |
| Molecular Weight | Calculated MW: 123 kDa, 124 kDa Observed MW: 130 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
